Comparison of live attenuated and inactivated influenza vaccines in schoolchildren in Russia: I. Safety and efficacy in two Moscow schools, 1987/88
Identifieur interne : 001E87 ( Main/Exploration ); précédent : 001E86; suivant : 001E88Comparison of live attenuated and inactivated influenza vaccines in schoolchildren in Russia: I. Safety and efficacy in two Moscow schools, 1987/88
Auteurs : A. N. Slepushkin [Russie] ; N. P. Obrosova-Serova [Russie] ; E. I. Burtseva [Russie] ; L. G. Rudenko [Russie] ; E. A. Govorkova [Russie] ; R. V. Vartanyan [Russie] ; A. I. Verestsinsky [Russie] ; N. I. Lonskaya [Russie] ; M. W. Harmon [États-Unis] ; T. Torok [États-Unis] ; G. I. Alexandrova [Russie] ; A. P. Kendal [Danemark, États-Unis]Source :
- Vaccine [ 0264-410X ] ; 1993.
English descriptors
- Teeft :
- Allantoic fluid, Antibody response, Antibody responses, Antibody rise, Attenuated, Attenuated vaccine, Attenuated vaccines, Confidence intervals, Confidence level, Detectable antibodies, Disease control, Dos, Epidemic strains, First dose, Former ussr, Illness data, Immunogenicity, Infectious virus, Influenza, Influenza illness, Influenza vaccines, Influenza virus, Intranasal, Intranasal placebo, Intranasal spray, Ivanovsky institute, Kendal, Local reactions, Many years, Measure vaccine immunogenicity, Natural infection, Other symptoms, Placebo, Postvaccine sera, Protective efficacy, Public health department, Reactogenicity, Respiratory illness, Russian federation, School nursing staff, Second dose, Second vaccination, Second vaccinations, Separate laboratory tests, Serological, Serological evidence, Serological results, Serum antibody, Serum samples, Single dose, Split virus, Statistical significance confidence intervals, Type virus, Vaccination, Vaccine, Vaccine efficacy, Virus vaccine, World health organization.
Abstract
Abstract: The performance of two doses of cold-adapted live attenuated vaccine versus one dose of whole-virus inactivated vaccine was compared in 8–15-year-old schoolchildren in two schools in Moscow, Russia, during the winter of 1987/88. Both vaccines gave rise to low frequencies of associated febrile or systemic reactions, but the inactivated vaccine, delivered by jet injector, did cause small local reactions in about half of the children. Immunogenicity was higher for both vaccines in antibody-free children, and higher levels of serum antibody were detected following use of inactivated vaccine. During the winter, influenza A (H3N2) and influenza B viruses circulated in Moscow. A clear outbreak of (H3N2) virus occurred in both schools, and infections with type B virus also occurred in one school. The influenza A/Philippines/2/82 (H3N2) component of both vaccines exhibited protective efficacy of about 40% (p < 0·05) against serologically proven infection caused by the antigenically drifted A/Sichuan/2/87 (H3N2)-like epidemic viruses in one school. In another school where illnesses associated with antibody rise were documented, efficacy was seen for both vaccines in reduction of illnesses, and of illnesses with serological evidence of infection, but statistical significance was not achieved.
Url:
DOI: 10.1016/0264-410X(93)90194-3
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001313
- to stream Istex, to step Curation: 001313
- to stream Istex, to step Checkpoint: 000C51
- to stream Main, to step Merge: 001F76
- to stream Main, to step Curation: 001E87
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Comparison of live attenuated and inactivated influenza vaccines in schoolchildren in Russia: I. Safety and efficacy in two Moscow schools, 1987/88</title><author><name sortKey="Slepushkin, A N" sort="Slepushkin, A N" uniqKey="Slepushkin A" first="A. N." last="Slepushkin">A. N. Slepushkin</name></author><author><name sortKey="Obrosova Serova, N P" sort="Obrosova Serova, N P" uniqKey="Obrosova Serova N" first="N. P." last="Obrosova-Serova">N. P. Obrosova-Serova</name></author><author><name sortKey="Burtseva, E I" sort="Burtseva, E I" uniqKey="Burtseva E" first="E. I." last="Burtseva">E. I. Burtseva</name></author><author><name sortKey="Rudenko, L G" sort="Rudenko, L G" uniqKey="Rudenko L" first="L. G." last="Rudenko">L. G. Rudenko</name></author><author><name sortKey="Govorkova, E A" sort="Govorkova, E A" uniqKey="Govorkova E" first="E. A." last="Govorkova">E. A. Govorkova</name></author><author><name sortKey="Vartanyan, R V" sort="Vartanyan, R V" uniqKey="Vartanyan R" first="R. V." last="Vartanyan">R. V. Vartanyan</name></author><author><name sortKey="Verestsinsky, A I" sort="Verestsinsky, A I" uniqKey="Verestsinsky A" first="A. I." last="Verestsinsky">A. I. Verestsinsky</name></author><author><name sortKey="Lonskaya, N I" sort="Lonskaya, N I" uniqKey="Lonskaya N" first="N. I." last="Lonskaya">N. I. Lonskaya</name></author><author><name sortKey="Harmon, M W" sort="Harmon, M W" uniqKey="Harmon M" first="M. W." last="Harmon">M. W. Harmon</name></author><author><name sortKey="Torok, T" sort="Torok, T" uniqKey="Torok T" first="T." last="Torok">T. Torok</name></author><author><name sortKey="Alexandrova, G I" sort="Alexandrova, G I" uniqKey="Alexandrova G" first="G. I." last="Alexandrova">G. I. Alexandrova</name></author><author><name sortKey="Kendal, A P" sort="Kendal, A P" uniqKey="Kendal A" first="A. P." last="Kendal">A. P. Kendal</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:7B281A64A94B83C945367914AF6977013BAE6733</idno><date when="1993" year="1993">1993</date><idno type="doi">10.1016/0264-410X(93)90194-3</idno><idno type="url">https://api.istex.fr/ark:/67375/6H6-0CKGJPH9-K/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001313</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001313</idno><idno type="wicri:Area/Istex/Curation">001313</idno><idno type="wicri:Area/Istex/Checkpoint">000C51</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000C51</idno><idno type="wicri:doubleKey">0264-410X:1993:Slepushkin A:comparison:of:live</idno><idno type="wicri:Area/Main/Merge">001F76</idno><idno type="wicri:Area/Main/Curation">001E87</idno><idno type="wicri:Area/Main/Exploration">001E87</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Comparison of live attenuated and inactivated influenza vaccines in schoolchildren in Russia: I. Safety and efficacy in two Moscow schools, 1987/88</title><author><name sortKey="Slepushkin, A N" sort="Slepushkin, A N" uniqKey="Slepushkin A" first="A. N." last="Slepushkin">A. N. Slepushkin</name><affiliation wicri:level="3"><country xml:lang="fr">Russie</country><wicri:regionArea>D.I. Ivanovsky Institute of Virology, Russian Academy of Medical Sciences, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Obrosova Serova, N P" sort="Obrosova Serova, N P" uniqKey="Obrosova Serova N" first="N. P." last="Obrosova-Serova">N. P. Obrosova-Serova</name><affiliation wicri:level="3"><country xml:lang="fr">Russie</country><wicri:regionArea>D.I. Ivanovsky Institute of Virology, Russian Academy of Medical Sciences, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Burtseva, E I" sort="Burtseva, E I" uniqKey="Burtseva E" first="E. I." last="Burtseva">E. I. Burtseva</name><affiliation wicri:level="3"><country xml:lang="fr">Russie</country><wicri:regionArea>D.I. Ivanovsky Institute of Virology, Russian Academy of Medical Sciences, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Rudenko, L G" sort="Rudenko, L G" uniqKey="Rudenko L" first="L. G." last="Rudenko">L. G. Rudenko</name><affiliation wicri:level="1"><country xml:lang="fr">Russie</country><wicri:regionArea>Institute of Experimental Medicine, St Petersburg</wicri:regionArea><wicri:noRegion>St Petersburg</wicri:noRegion></affiliation></author><author><name sortKey="Govorkova, E A" sort="Govorkova, E A" uniqKey="Govorkova E" first="E. A." last="Govorkova">E. A. Govorkova</name><affiliation wicri:level="3"><country xml:lang="fr">Russie</country><wicri:regionArea>D.I. Ivanovsky Institute of Virology, Russian Academy of Medical Sciences, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Vartanyan, R V" sort="Vartanyan, R V" uniqKey="Vartanyan R" first="R. V." last="Vartanyan">R. V. Vartanyan</name><affiliation wicri:level="3"><country xml:lang="fr">Russie</country><wicri:regionArea>D.I. Ivanovsky Institute of Virology, Russian Academy of Medical Sciences, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Verestsinsky, A I" sort="Verestsinsky, A I" uniqKey="Verestsinsky A" first="A. I." last="Verestsinsky">A. I. Verestsinsky</name><affiliation wicri:level="3"><country xml:lang="fr">Russie</country><wicri:regionArea>D.I. Ivanovsky Institute of Virology, Russian Academy of Medical Sciences, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Lonskaya, N I" sort="Lonskaya, N I" uniqKey="Lonskaya N" first="N. I." last="Lonskaya">N. I. Lonskaya</name><affiliation wicri:level="3"><country xml:lang="fr">Russie</country><wicri:regionArea>L.A. Tarasevitch State Institute for Standards and Control of Biological Medical Preparations, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Harmon, M W" sort="Harmon, M W" uniqKey="Harmon M" first="M. W." last="Harmon">M. W. Harmon</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>WHO Collaborating Center for Influenza, Centers for Disease Control, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Torok, T" sort="Torok, T" uniqKey="Torok T" first="T." last="Torok">T. Torok</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>WHO Collaborating Center for Influenza, Centers for Disease Control, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Alexandrova, G I" sort="Alexandrova, G I" uniqKey="Alexandrova G" first="G. I." last="Alexandrova">G. I. Alexandrova</name><affiliation wicri:level="1"><country xml:lang="fr">Russie</country><wicri:regionArea>Institute of Experimental Medicine, St Petersburg</wicri:regionArea><wicri:noRegion>St Petersburg</wicri:noRegion></affiliation></author><author><name sortKey="Kendal, A P" sort="Kendal, A P" uniqKey="Kendal A" first="A. P." last="Kendal">A. P. Kendal</name><affiliation wicri:level="1"><country xml:lang="fr">Danemark</country><wicri:regionArea>To whom correspondence should be addressed at: World Health Organization, Regional Office for Europe, Scherfigsvej 8, DK-2100 Copenhagen</wicri:regionArea><wicri:noRegion>DK-2100 Copenhagen</wicri:noRegion></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>WHO Collaborating Center for Influenza, Centers for Disease Control, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Vaccine</title><title level="j" type="abbrev">JVAC</title><idno type="ISSN">0264-410X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1993">1993</date><biblScope unit="volume">11</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="323">323</biblScope><biblScope unit="page" to="328">328</biblScope></imprint><idno type="ISSN">0264-410X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0264-410X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Allantoic fluid</term><term>Antibody response</term><term>Antibody responses</term><term>Antibody rise</term><term>Attenuated</term><term>Attenuated vaccine</term><term>Attenuated vaccines</term><term>Confidence intervals</term><term>Confidence level</term><term>Detectable antibodies</term><term>Disease control</term><term>Dos</term><term>Epidemic strains</term><term>First dose</term><term>Former ussr</term><term>Illness data</term><term>Immunogenicity</term><term>Infectious virus</term><term>Influenza</term><term>Influenza illness</term><term>Influenza vaccines</term><term>Influenza virus</term><term>Intranasal</term><term>Intranasal placebo</term><term>Intranasal spray</term><term>Ivanovsky institute</term><term>Kendal</term><term>Local reactions</term><term>Many years</term><term>Measure vaccine immunogenicity</term><term>Natural infection</term><term>Other symptoms</term><term>Placebo</term><term>Postvaccine sera</term><term>Protective efficacy</term><term>Public health department</term><term>Reactogenicity</term><term>Respiratory illness</term><term>Russian federation</term><term>School nursing staff</term><term>Second dose</term><term>Second vaccination</term><term>Second vaccinations</term><term>Separate laboratory tests</term><term>Serological</term><term>Serological evidence</term><term>Serological results</term><term>Serum antibody</term><term>Serum samples</term><term>Single dose</term><term>Split virus</term><term>Statistical significance confidence intervals</term><term>Type virus</term><term>Vaccination</term><term>Vaccine</term><term>Vaccine efficacy</term><term>Virus vaccine</term><term>World health organization</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The performance of two doses of cold-adapted live attenuated vaccine versus one dose of whole-virus inactivated vaccine was compared in 8–15-year-old schoolchildren in two schools in Moscow, Russia, during the winter of 1987/88. Both vaccines gave rise to low frequencies of associated febrile or systemic reactions, but the inactivated vaccine, delivered by jet injector, did cause small local reactions in about half of the children. Immunogenicity was higher for both vaccines in antibody-free children, and higher levels of serum antibody were detected following use of inactivated vaccine. During the winter, influenza A (H3N2) and influenza B viruses circulated in Moscow. A clear outbreak of (H3N2) virus occurred in both schools, and infections with type B virus also occurred in one school. The influenza A/Philippines/2/82 (H3N2) component of both vaccines exhibited protective efficacy of about 40% (p < 0·05) against serologically proven infection caused by the antigenically drifted A/Sichuan/2/87 (H3N2)-like epidemic viruses in one school. In another school where illnesses associated with antibody rise were documented, efficacy was seen for both vaccines in reduction of illnesses, and of illnesses with serological evidence of infection, but statistical significance was not achieved.</div></front></TEI><affiliations><list><country><li>Danemark</li><li>Russie</li><li>États-Unis</li></country><region><li>District fédéral central</li><li>Géorgie (États-Unis)</li></region><settlement><li>Moscou</li></settlement></list><tree><country name="Russie"><region name="District fédéral central"><name sortKey="Slepushkin, A N" sort="Slepushkin, A N" uniqKey="Slepushkin A" first="A. N." last="Slepushkin">A. N. Slepushkin</name></region><name sortKey="Alexandrova, G I" sort="Alexandrova, G I" uniqKey="Alexandrova G" first="G. I." last="Alexandrova">G. I. Alexandrova</name><name sortKey="Burtseva, E I" sort="Burtseva, E I" uniqKey="Burtseva E" first="E. I." last="Burtseva">E. I. Burtseva</name><name sortKey="Govorkova, E A" sort="Govorkova, E A" uniqKey="Govorkova E" first="E. A." last="Govorkova">E. A. Govorkova</name><name sortKey="Lonskaya, N I" sort="Lonskaya, N I" uniqKey="Lonskaya N" first="N. I." last="Lonskaya">N. I. Lonskaya</name><name sortKey="Obrosova Serova, N P" sort="Obrosova Serova, N P" uniqKey="Obrosova Serova N" first="N. P." last="Obrosova-Serova">N. P. Obrosova-Serova</name><name sortKey="Rudenko, L G" sort="Rudenko, L G" uniqKey="Rudenko L" first="L. G." last="Rudenko">L. G. Rudenko</name><name sortKey="Vartanyan, R V" sort="Vartanyan, R V" uniqKey="Vartanyan R" first="R. V." last="Vartanyan">R. V. Vartanyan</name><name sortKey="Verestsinsky, A I" sort="Verestsinsky, A I" uniqKey="Verestsinsky A" first="A. I." last="Verestsinsky">A. I. Verestsinsky</name></country><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Harmon, M W" sort="Harmon, M W" uniqKey="Harmon M" first="M. W." last="Harmon">M. W. Harmon</name></region><name sortKey="Kendal, A P" sort="Kendal, A P" uniqKey="Kendal A" first="A. P." last="Kendal">A. P. Kendal</name><name sortKey="Torok, T" sort="Torok, T" uniqKey="Torok T" first="T." last="Torok">T. Torok</name></country><country name="Danemark"><noRegion><name sortKey="Kendal, A P" sort="Kendal, A P" uniqKey="Kendal A" first="A. P." last="Kendal">A. P. Kendal</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001E87 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001E87 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:7B281A64A94B83C945367914AF6977013BAE6733
|texte= Comparison of live attenuated and inactivated influenza vaccines in schoolchildren in Russia: I. Safety and efficacy in two Moscow schools, 1987/88
}}
| This area was generated with Dilib version V0.6.33. |  |